Gradient is a medical device company headquartered in Paris, developing an innovative minimally invasive ultrasound-based catheter for the treatment of pulmonary hypertension. The company was established in 2020 by Sofinnova MD Start, and leverages intellectual property developed at Stanford University.

Gradient’s novel technology aims to treat patients with pulmonary hypertension by reducing sympathetic input into the pulmonary vasculature. The company’s initial focus is the Group 2 pulmonary hypertension patient population, which consists of patients with heart failure and associated high pulmonary vascular resistance. Gradient’s minimally invasive device, designed for use in the pulmonary arteries, harnesses therapeutic ultrasound energy to perform the denervation procedure.